Conolidine alkaloid for chronic pain for Dummies
Most recently, it has been discovered that conolidine and the above derivatives act on the atypical chemokine receptor three (ACKR3. Expressed in equivalent parts as classical opioid receptors, it binds to some wide array of endogenous opioids. Not like most opioid receptors, this receptor acts like a scavenger and won't activate a second messenger